This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
Author : Anton G. Kutikhin Release : 2013-08-28 Publisher : Springer Science & Business Media ISBN : 3034806884 File Size : 47.38 MB Format : PDF, ePub Download : 206 Read : 519